Naveen Jain on the Human Ecosystem and Personalized Optimization of Your Gut Health

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Katie: Hiya and welcome to “The Wellness Mama Podcast.” I’m Katie from wellnessmama.com and wellnesse.com, that’s wellness with an E on the top. And I’m right here right now with my buddy, Naveen, who’s an intensely curious entrepreneur who has been taking over some massive, audacious concepts to push humanity ahead. He’s the writer of the award-winning e-book “Moonshots: Making a World of Abundance,” and his present moonshot adventures are Viome and Moon Specific, which is an area firm. However as a serial entrepreneur, he’s additionally based InfoSpace, Intelius, and Expertise Clever, amongst others.

And his present work is in Viome Life Sciences, which was based in 2016 with a mission of creating sickness elective by predicting and stopping power illness by way of a deeper understanding of a person’s biology at a molecular stage. And it’s constructed on an AI-driven platform that analyzes the interplay between meals, our microbiome, and our human selves to develop precision suggestions to stop and reverse power illness. He’s additionally the vice-chairman of the board at Singularity College, and on the board of XPRIZE Basis. He’s been the recipient of many issues together with Entrepreneur of the Yr, Most Artistic Particular person by Quick Firm, Prime 20 Entrepreneurs, and plenty of extra.

On this episode, we discuss concerning the human ecosystem and customized optimization of your intestine well being and your general well being. We discuss concerning the cause the intestine impacts all the physique. Why it’s not simply genetics from our dad and mom however really our ecosystem inside our intestine that controls our physique. Why 70% of the immune system is within the intestine. How microbiome stability begins at delivery and even earlier than. How 90% of serotonin is produced within the intestine, not the mind. What makes up the ecosystem of the intestine. We get fairly granular on this one.

The distinction between DNA and gene expression. How some meals may be good for some individuals and never others, and know which is finest for you, but in addition, the universally dangerous meals. Why there are some universality dangerous ones however not universally good ones. Why he doesn’t suggest harsh merchandise that kill micro organism within the mouth or within the intestine. The actual cause it’s essential to chew your meals very well earlier than swallowing, and a lot extra. Lot’s of sensible information on this episode. Additionally, numerous hyperlinks to be taught extra within the present notes at wellnessmama.fm, so test these out. However with out additional ado, let’s be a part of Naveen Jain. Naveen, welcome again.

Naveen: Effectively, Katie, so good to see you lastly after an extended, very long time.

Katie: I’m so excited we get to have a dialog and get to file it and share it right now, and we’re gonna discuss quite a bit about intestine well being and even past intestine well being, how this impacts the well being of the entire physique. Earlier than we do, although, I might say you’re the one individual I do know in actual life who has a Moon rock assortment. And so, I might love so that you can simply discuss this as a result of I feel you’re my solely hobbyist Moon rock collector.

Naveen: Effectively, I feel, Katie, , to me, the Moon is symbolic. It’s symbolic of what humanity is able to doing. So, to me, going to the Moon is a means of expressing that there’s nothing that’s inconceivable for us to do. Despite the fact that it’s referred to as “Moonshots” that individuals thought was troublesome, if not inconceivable to do and having, , now to have the ability to go to the Moon and to me, the gathering of house rocks really was simply merely a pastime of in a position to maintain one thing in your hand. That could be even earlier than the delivery of our planet. And it offers you some concept of how fragile we’re that if we don’t care for ourselves, our planet, we as humanity might not survive. As a species, we might not survive.

So, , concept of when somebody says, “I’m actually nervous about our planet,” ask the planet and planet will let you know, “Don’t you are worried about me as a result of we…” Planet will do exactly tremendous however human species might not survive. Similar to dinosaurs. And to me, having a Moon rock merely jogs my memory that all of us are linked collectively. When one thing outdoors us goes unsuitable, we as inside ecosystem can even be impacted, proper. And that’s coming all the way down to, , in case you take a look at what’s above, so under is actually what’s outdoors the ecosystem and the universe impacts us, and our ecosystem inside us impacts the universe.

Katie: I really like that you just mentioned it like that as a result of I interviewed my oldest son on this podcast a pair hundred episodes in the past when he launched a cookbook and him as effectively. And I requested him that query. You realize, your technology’s gonna face quite a bit within the environmental and local weather stuff. And, I raised this query and he goes, “Effectively, mother, you’re really asking the unsuitable query as a result of the…”

Naveen: Oh, I find it irresistible, I find it irresistible.

Katie: He mentioned, “The planet is a self-correcting organism. It’s gonna heal itself. It’s only a query of whether or not we get to remain right here when it does. And we have to be asking how we may be extra synergistic inside an setting that’s greater than us.”

Naveen: That’s the good reply. That’s precisely how I might see it that…, when individuals say, “Aren’t you nervous concerning the planet?” I say, “That’s not the query you need to be asking.” It’s, “Are we nervous concerning the human species?” That’s what we must be asking.

Katie: Which is an ideal segue as a result of that’s one thing that you’re intimately concerned with and I might say not nervous about however working to resolve. My listeners are fairly well being savvy and perceive or at the least have a passing understanding that intestine well being impacts the entire whole physique. However I really feel like this idea is…effectively, we’ve identified features of it for a very long time. We’re seeing a lot extra analysis about it proper now. And we’re…because of firms like Viome, we’ve many extra tangible instruments to truly perceive and begin to do one thing about that. However to start out broad, type of give us an outline of what we imply by the well being of the intestine impacts the well being of the entire physique.

Naveen: So, effectively, to begin with, , let’s simply begin from the start. We as human beings will not be merely a product of the DNA from our mother and pa. What we’re is a symbiotic ecosystem, and in that ecosystem, 99% of all of the genes which can be really expressed in our human physique will not be our personal. They arrive from these microbes which can be in our mouth, in our intestine, throughout us. So, think about…I imply, there’s actually…if we take a look at the human beings as such when it comes to all of the genes which can be expressed that makes us who we’re, they aren’t people. They’re largely microbial. We’re residing of their world. They don’t reside in our world, proper.

So, after we perceive that, , despite the fact that you could possibly argue that they’re the puppet masters and we’re merely the host or puppet for his or her profit, and you could possibly argue sometime that perhaps they really created us to unfold them round, perhaps they created us to allow them to rule the world, proper, however in all honesty, we coevolved collectively. In coevolution what occurs is we feed them and we give them a pleasant and heat and cozy place to remain. In flip, they feed us the vitamins that our physique wants to truly be wholesome, proper. So, think about from the time a child is born, and I feel that is one thing that most individuals don’t notice, that within the first couple of days of mom’s breast milk is filled with oligosaccharides. And that can not be digested by the human physique. That’s there just for the microbes within the intestine to have the ability to convert into vitamins. Meaning it’s to create the ecosystem inside us.

Now think about what nature is telling us, that we simply created a offspring and the easiest way to maintain this offspring wholesome is to not feed it however to feed them who’re going to maintain the offspring wholesome. And because the child goes by way of the delivery canal, that is the primary publicity the infant will get to the entire world of microbiome. It will get…utterly inhales the microbiome because the child’s going by way of delivery canal. And sadly, a number of the moms for apparent causes find yourself getting a C-section. They really…the infants will not be going by way of the identical…they’re uncovered to pores and skin microbiome somewhat by way of the delivery canal, the microbiome that they’d get by way of the delivery canal. And that may be a essentially…the infant, when it’s born, is definitely…the character has created in a means that the microbes get launched into the infant on the time of the delivery and that really now turns into a coevolution course of. And the mom’s breast milk begins to feed these microbes to create this ecosystem.

And because the intestine microbiome begins to get wholesome, it begins to coach our immune system. And I feel that is the elemental half that individuals want to know. Seventy p.c of our immune system is alongside our intestine lining. In actual fact, all of the analysis exhibits that how intestine microbiome is continually coaching our immune system what’s a buddy and what’s a foe, proper. So, in some sense, in case you take a look at the human physique, there’s a tube that goes by way of us. There’s a prime of the tube in your mouth after which there’s the underside of the tube, and then you definately begin to have a look at all alongside the strains there’s a large quantity of microbial existence there. And so they in truth are always interacting with our immune system and the immune system is now understanding when there may be really a pathogen that’s coming by way of the meals or the pathogen that’s coming by way of the skin world, react to it. And these microbes are the primary sign that tells the immune techniques, “This isn’t good. Go do one thing about it, proper.”

And I feel to me, that symbiotic relationship breaks down when there’s a dysbiosis within the intestine. So, I feel as your son identified, not simply the planet however even the human physique is designed to heal itself. The human physique is designed to be in homeostasis. And any time…and whether or not we minimize our pores and skin or whether or not there may be some kind of pathogen or we get some kind of a illness, it usually is designed to heal itself if our physique is in stability. So, when there are intestine microbial actions and the human host are always in sync and wholesome and our immune system is wholesome, then our physique will really heal itself. When there’s a dysbiosis or imbalance of the intestine microbiome, that is the place the unease occurs. When your physique just isn’t comfy, you get illness which we name illness.

Katie: Yeah, so many essential factors you simply mentioned to unpack. And I feel the primary being that we actually are extra bacterial than human and also you…right here you mentioned you might be what you eat but it surely goes to this point past that. It’s not even you might be what you eat and even you might be what you eat-eat, however what your intestine micro organism eats and the way it grows. And I really like that you just introduced up the delivery canal factor as a result of I’m a doula and I’ve really helped in a number of C-section births with feeding the infant, as a result of such as you mentioned, in case you don’t…the infant is of course meant to seed their intestine by way of the delivery canal. And if that doesn’t occur, such as you mentioned, they’re seeding to the hospital room, to pores and skin, to probably disinfectants which can be in that room, every kind of issues. And we all know that this intestine micro organism at delivery, increasingly more we be taught, units you up in your complete life. But additionally, the excellent news is…and I do know that Viome does quite a lot of analysis on this. All just isn’t misplaced in case you don’t get an ideal begin. We now have the power to type of get a snapshot and look within the intestine in a very distinctive means after which optimize to enhance somebody’s well being going ahead.

And in addition, such as you mentioned, the physique’s pure state is well being. It’s not usually that we have to do something drastic. We have to get out of our personal means and simply take away the issues which can be maintaining the physique from being wholesome or perhaps typically give it little further vitamins to assist get there. Discuss a little bit bit concerning the science of Viome and what we’re testing as a result of this know-how didn’t even exist a pair a long time in the past, and now we’ve such superb information from this.

Naveen: Effectively, it’s very fascinating is this concept of, …in case you return and take a look at couple of a long time in the past, it was really the micro organism and all these organisms have been thought of as an enemy of the human physique. That’s the minute you see them, your job is to kill them as shortly as doable as a result of they’ll’t presumably be there for our good, proper. And as we began to be taught extra concerning the human physique, we realized that the majority of those organisms are literally commensal. They’re alleged to be there they usually in truth…after we feed them issues like, …in olden days, after we have been residing within the savannas of Africa, we’ll pull out a leaf or we’ll pull out the basis and eat it. That’s filled with fiber. These fibers are literally what our intestine microbes eat, and people intestine microbes, by consuming these fibers, really flip them into brief chain fatty acids. Issues like butyric, issues like acetate, these have been all of the vitamins that our physique wanted.

In actual fact, in case you begin to consider it, 90% of all of the serotonin is definitely produced in our intestine, not in our mind. So, in case you actually take into consideration all of the issues which can be being executed within the intestine and the way what occurs within the intestine doesn’t merely keep within the intestine, it really impacts the entire physique together with our mind to coming again to it, Katie, that you just identified. What occurs in our intestine impacts our temper. So, whether or not it’s a despair or nervousness or, , you’ll be able to name them any names you need, , a lot of this stuff together with autism is now linked instantly into the intestine microbiome. In actual fact, they’ve executed now the analysis the place they did merely a microbial transplant referred to as a fecal transplant they usually have been in a position to in truth present that youngsters with autism, their autistic signs went down by 50% even after two years simply by merely doing the microbial transplant. They have been in a position to present while you took an individual that has a despair a microbial transplant or nervousness, it may be transferred just by transferring the microbiome into one other species. And so they’ve executed them in mice they usually’ve executed that in truth in people, and clearly, it was executed by mistake however that’s really the way it occurred.

In actual fact, what’s actually fascinating is habit. And so they’ve proven the identical factor. They took…there have been 17 individuals on the analysis that have been utterly hooked on alcohol. And people individuals, they gave them a fecal transplant from individuals who really had no habit. And these individuals’s habit went away. Now think about that, that our intestine microbiome are controlling our mind when it comes to what to do. That’s what the habit is, proper. And I feel that’s actually phenomenal.

And now what we’re studying is each kind of most cancers…in truth what they’ve now checked out is each single stable tumor has microbes inside that tumor. Take into consideration {that a} second, the microbes are contained in the tumor. And what we discovered most fascinating was there may be microbial peptides being displayed on the floor of the tumor. Now, why would a tumor that’s an organism desirous to survive would ever show a microbial peptide until it’s there to idiot our immune system into pondering that is self and protects the tumor in opposition to the immune system attacking, proper?

Now, think about what…one other factor that’s most fascinating I discovered was while you do immunotherapy, it really works about one-third of the time. And the individuals the place the immunotherapy doesn’t work, within the 70% of the those who immunotherapy didn’t work, they merely have been in a position to do a change of their intestine microbiome and the identical immunotherapy began working. So, our intestine microbiome just isn’t solely there to maintain us wholesome from all of the ailments right now we name the totally different names. Coronary heart ailments, it’s coming from our intestine microbes really producing issues like trimethylamine or TMA. TMA will get absorbed within the blood and our liver converts them into TMAO, trimethylamine oxide. In actual fact, we are able to now take a look at issues like LDL manufacturing which is a nasty ldl cholesterol manufacturing and see how microbial actions and microbial metabolites really change the LDL manufacturing. You’re in a position to have a look at how…what’s taking place in your intestine, how are we altering the inflammatory markers in our host. So, we’re in a position to measure the intestine exercise and the human host exercise, all their cytokines. So, we’re taking a look at each interleukins, we’re taking a look at the entire inflammatory markers to see how they’re altering with the intestine microbial exercise.

And so, anyway, the purpose I’m making an attempt to make is that you just talked about one thing about these micro organism, and I simply need individuals to know the microorganisms will not be simply micro organism. They’re predominantly micro organism however in addition they encompass yeast, viruses and even the RNA viruses or fungus or mould. All of this stuff are literally the entire ecosystem and the most important half in truth in case you seen virtually 10 to 1 if no more is definitely phages. And phages are the viruses that infect the micro organism. And in case you take a look at any nature whether or not you’re trying within the swamp otherwise you’re trying on the intestine microbiome, in truth there are 10 instances extra phages than the micro organism alone. And which means these viruses that infect micro organism are modifying the bacterial…the organism, the capabilities of those micro organism that in truth modifications how these micro organism behave when it comes to what capabilities they’re performing.

So once more, what’s actually fascinating is by taking a look at what organisms are there, won’t ever let you know what’s going on in your physique. In actual fact, their capabilities are what makes the distinction. Meaning what they’re producing can…is actually the one factor that issues what these intestine microbes are producing, not who they’re. And I feel, Katie, you in all probability know that quite a lot of the individuals like Akkermansia muciniphila. A number of the firms are promoting them as a probiotic with out realizing that Akkermansia may be good for some individuals and actually it’s the primary cause for inflicting a number of sclerosis, and it has additionally been instantly linked to Alzheimer’s, proper. So now give it some thought. The identical organism can do one thing good for one individual and might do one thing actually dangerous in one other individual. So, taking one thing blindly, taking any complement, any probiotic, any prebiotic blindly is definitely not good for you as a result of your physique is totally totally different than different individual’s physique. The identical organism or similar probiotic may be good for somebody and could possibly be dangerous for one more individual. And that’s the most important studying we’ve had within the final six years.

Katie: Yeah, I really like that you just introduced up the fecal microbiota switch as effectively. I’ve seen a number of the science on this and… , caveat, this isn’t one thing to aim at dwelling but it surely’s fairly superb what they’re undertaking in labs with some actually focused and really particular methods of doing that. And I really feel like in a way, that is additionally one thing you’ll be able to accomplish with out having to go to that excessive if what you’re working with. And for the final two years, I’ve been saying, , early on in well being and wellness, I might discover out data, learn research and be so excited and write about it, and I’ve realized increasingly more over the past 15 years every little thing is so customized and so individualized. And so now when individuals ask me like, “What precisely did you do to reverse your Hashimoto’s?” I say, “You realize, I can let you know what I did but it surely’s not gonna work the identical for you. It may be an concept with the start line but it surely’s not gonna be your blueprint. Every of our blueprints is gonna be very, very totally different.”

Which is why I really like now increasingly more entry to those at-home testing whether or not it’s issues like Viome, even now blood testing obtainable at dwelling, genetic testing simply so we are able to have extra data and entry. And I’ve mentioned so many instances on right here we’re every our personal major healthcare supplier. On the finish of the day, it’s nice to work with medical doctors however we’re every our personal major healthcare supplier. And I really feel like having instruments in our pocket that allow us be simpler at that may actually, actually make a distinction. So, let’s discuss a little bit bit extra concerning the personalization side of this as a result of I additionally am curious…, I do know you mentioned every little thing is so totally different. What’s good for one individual is perhaps not for one more. Are there any issues which can be type of universally dangerous that you just’re discovering in Viome? Like, I might put perhaps processed vegetable oils on the don’t cross listing, however I’m curious what you’re seeing within the information.

Naveen: Yeah. So to begin with, it’s actually fascinating. I feel you phrased it appropriately. There isn’t any such factor as common wholesome meals. And which means there isn’t a such factor that’s good for everybody. Meaning the identical meals may be good for you or dangerous for somebody. Nevertheless, there are some common unhealthy issues that you could know. So, there isn’t a common wholesome factor however there are universally unhealthy issues. Sugar is a type of unhealthy issues. There isn’t any one who says, “The sugar is sweet for me, proper.” In order that’s really having a fried, , fried meals. So, all fried stuff, it’s simply dangerous for everybody. Consuming quite a lot of sugar, it’s simply dangerous for everybody. Nevertheless, what we discover most fascinating is that analyzing the human physique and analyzing based mostly on what’s going on and what’s dynamically altering in your physique…and I feel quite a lot of the people who find themselves listening to it, I need individuals to know the distinction between a DNA which is static. So when individuals do their DNA take a look at, it tells you what’s inherently there in your physique. It doesn’t let you know what is definitely happening in your physique. Meaning…if, Katie, you permit me, I’m gonna clarify the DNA as a result of I feel to me lots of people get very confused about what DNA is.

So, each a part of our physique is equivalent DNA. Meaning you take a look at my hair, you take a look at my eyes, you take a look at my tooth, you take a look at my nails, you take a look at my finger, it’s precisely the identical DNA. Then why is it we don’t have the eyes rising on my fingers and the nails rising on my head? Similar DNA. And the reply is there’s…when some genes are overexpressed, some genes are underneath expressed, the identical DNA can turn into eye, similar DNA can turn into nail, similar DNA can turn into pores and skin, similar DNA can turn into coronary heart cells or neurons or issues like that, proper. So, level is DNA is like an alphabet and the story you might be writing is definitely what’s being expressed. It’s referred to as RNA. So, RNA tells you the story that’s being written for you proper now and DNA tells you each doable factor that may occur. And that’s one factor.

So, what we do at Viome, Katie, is we take a look at your gene expression and what gene expression tells us is what story your intestine microbes are writing. What story your human host is writing. And now I’m gonna come again and let you know…some information to share with you in direction of the top. As soon as we perceive all that’s happening, we’re in a position to then let you know, “Hey, don’t eat broccoli or cabbage as a result of your sulfide manufacturing in your intestine is simply too excessive and the sulfide want sulfates to provide sulfide and the broccoli and cabbage are very excessive in sulfate so it is best to minimize it down, proper.”

We will let you know that…lots of people will let you know go take vitamin B3. However vitamin B3’s really not good for you when you’ve got excessive uric acid manufacturing. So don’t take vitamin B3 when you’ve got excessive uric acid manufacturing. Equally, everybody will let you know, “Hey, take curcumin and turmeric. It’s actually good anti-inflammatory.” It’s. Nevertheless, when your bile acid manufacturing could be very excessive, you don’t need to take curcumin as a result of it’s going to transform into bile salt that’s gonna trigger extra irritation. Lots of people assume by some means taking NAD or NR, and NMN which is precursor to NAD is definitely enhance your longevity. It’s true for some individuals it could try this, however for others it really will hurt you when you’ve got excessive mobile senescence, or when you’ve got excessive inflammatory exercise. You don’t need to be taking further NAD as a result of that’s gonna enhance the mitochondrial biogenesis that’s going to extend extra free radicals, gonna enhance excessive mobile senescence, proper.

So, the concept actually is that you need to be taught what is occurring earlier than you deal with your physique like a black field. And I feel you’ve mentioned it proper, that we’re simply…we’re the CEO of our personal well being. We’re those who must know what is occurring in our physique as a result of our major care physician…I don’t find out about you, Katie. After I go to my major care physician, by the point I begin talking, he’s already writing the prescription. I imply, actually, the phrase he says… “Oh, did you say coughing? Right here it’s. Did you say this? Give me the in poor health, I’ll provide the tablet.” And that’s all they’re merely doing. They don’t must…they don’t care to know what’s inflicting that to occur in my physique. Like, you had Hashimoto, or in case you had any kind of an autoimmune illness, the very first thing they let you know is simply take the immune suppression medicine and suppress the symptom. Not fear about what’s inflicting it, and that may be a elementary downside that our healthcare system has is that our medical industrial advanced, everybody makes cash after we are sick and nobody makes cash after we are wholesome. And so, we determined to vary that. In my world of the long run, Katie, we imagine that…I feel similar to you simply mentioned, the way forward for healthcare goes to be delivered at dwelling, not on the hospitals.

And the medicines of the long run are gonna come from a farm, not a pharmacy. And that’s going to be the most important change you’ll begin to see us taking management of our personal well being. And I feel COVID has been one of many…I might say in case you look again at COVID 10 years from now, it will likely be the most important inflection level that occurred in humanity’s notion of that we as people have management our personal actions and our actions have well being penalties.

Katie: Completely. I feel so many good silver linings and educating moments in COVID and other people spent extra time at dwelling and with their households cooking dinner at dwelling. There have been quite a lot of nice outcomes, as exhausting because it was for many individuals. I feel we are able to deal with these positives. And I really like your clarification of DNA and the way it goes past simply your genetics. It’s about how they’re expressed and the way that’s managed within the intestine. And I’d like to go a little bit bit deeper about Viome as a result of I do know I talked to you years in the past about this and also you guys have made some massive advances since then. So, discuss type of the snapshot of what Viome is testing after which how individuals are making modifications based mostly on that and what they’re seeing.

Naveen: Sure. So clearly, Katie, a few years in the past we did a intestine intelligence chart that merely measured your intestine well being. After which we realized that that was actually good but it surely didn’t inform us how these intestine modifications have been impacting us and the human physique. And so, we now launched…about two years in the past throughout COVID really, we launched our well being intelligence take a look at that measures your blood and it measures your stool, and by doing the finger prick blood, so that you don’t must go to a lab. It’s a easy finger prick blood, couple of drops of your blood. And your starch of your stool. We’re in a position to now take a look at each your intestine well being and your human host and in a position to now let you know what’s your organic age. And that tells you not solely, , how effectively or how poorly your physique is growing older in comparison with your chronological age.

So, to offer you an concept, I’m now gonna be 63 in September and my organic age is all the way down to 50. And that tells you that actually that my physique is performing on the stage after I was 50. And I really feel it. I run up the steps two stairs at a time and I’ve extra vitality than in truth I had after I was 50. And that merely tells you what your organic age is. Then we offer you immune well being. Meaning how effectively are you protected in opposition to in case you have been to catch flu or chilly or any kind of pathogen, how effectively your physique is ready to shield itself? And that’s your immune well being. Your mobile well being. That tells you the way effectively your cells are in a position to bear the issues which can be happening within the human physique. Mitochondrial well being, that’s your vitality manufacturing facility. How effectively the mitochondrial well being is performing as a result of if it’s not, you get mind fog, you’re feeling fatigued, you’re feeling drained. We offer you clearly your intestine well being.

And now that is one thing new that we’re gonna be launching in June and we’re launching a brand new product referred to as full physique intelligence. And for the primary time, we’re gonna be analyzing all the way in which from prime of your tube, your saliva, your stool and blood, all three on the similar time. And by taking a look at that, we’re additionally gonna have the ability to present you some further insights resembling your coronary heart and metabolic well being. We’re gonna be providing you with your mind and cognitive well being. We’re gonna have the ability to present you your oral well being resembling your gum well being, your tooth well being and all of the gum, …leaky gum as an alternative of simply leaky intestine. We’ll have the ability to present you the way effectively your boundaries of your gums are performing in order that microbes will not be going into your blood.

And different factor we do now which we didn’t do till a few yr in the past is while you do a take a look at, not solely you get your deep perception what’s taking place in your physique and never simply let you know listed below are the meals which can be good for you and right here is why. Listed below are the meals it is best to keep away from and why. We used to let you know listed below are the dietary supplements it is best to take. Now we transcend that, Katie. We’re in a position to let you know you solely want 22 milligram of berberine daily. You want 17 milligram of elderberry daily. You want 79 milligram amylase daily. And we undergo each vitamin, minerals, herbs, meals extracts, digestive enzymes, amino acids, probiotics, prebiotics, and we actually make these for you on demand.

There isn’t any premade stuff. Consider it like a compounding pharmacy. There are robotics compounding pharmacy. It says, these capsules are being made for Katie. Go to bin quantity 17, get 17 milligram of elderberry. Go to bin quantity 29, get 27 milligram of berberine. And we actually take all of the strawberry extract right here, put this factor right here. And by the way in which, as soon as we get the powder, we make the capsules and ship them off to you each month. And as your physique modifications, we modify your dietary supplements on the similar time. So, each time you retest, we are saying, “Oh, you don’t want amylase anymore. What you really want is butyrate now,” proper. And we actually are in a position to regulate your…as your physique is altering, we adapt the vitamin that your physique wants. And people are the brand new issues that I’m tremendous enthusiastic about.

Different issues that I’m actually, actually enthusiastic about…and we’ve not talked to anybody but about it. We’re gonna be launching in June additionally our most cancers detect. And that is gonna…first time as a client you’ll have the ability to spit in a tube and with 95% specificity and 90% sensitivity, we’ll have the ability to let you know when you’ve got any oral most cancers or throat most cancers. After which we’ll have the ability to really join you with a physician to have the ability to do one thing about it. So, if you’re above…over 50 years outdated or have any historical past of smoking, vaping, chewing tobacco, you’ll have the ability to really at dwelling do a take a look at and truly know that you just’re not at a threat of growing a most cancers proper now. Otherwise you’re growing a most cancers proper now.

Katie: Yeah. That is so leading edge and I feel simply to focus on what you mentioned, that is actually fascinating information of mainly machine studying and AI and this adaptive know-how. And since you’ve now examined hundreds and hundreds, in all probability a whole lot of hundreds of individuals, then the algorithm has entry to all this data so it might probably proceed to get increasingly more specialised and direct with the suggestions and be taught your individual physique over time. So, you’re getting this sort of ongoing, correct image which I feel is so fascinating.

Naveen: Yeah. So, Katie, we’ve analyzed over 350,000 samples already. And that has given us this…, the a part of being the…a part of that Viome ecosystem is each single one who joins profit from the opposite 350,000 samples that we’ve analyzed they usually contribute to the ecosystem, and our AI and machine studying is continually getting higher. And for each single one who joins profit themselves and advantages the humanity on the similar time as a result of now the extra we be taught, the higher suggestions we are able to make for everybody. So, earlier than we simply solely may take a look at your stool. Now we take a look at stool plus blood. Now it’s stool plus blood plus saliva. And we’re gonna launch…the subsequent factor will likely be with urine. After which we’re gonna begin to have a look at different biomarkers in your physique. So, our suggestions get increasingly more exact as we be taught increasingly more concerning the human physique. And our actual hope is, , in my lifetime we’ll have the ability to perceive what causes the onset of a power illness and what causes them to progress and to have the ability to forestall them from taking place within the first place, to diagnose them early once they really do occur, and to give you a treatment for these ailments. Not merely handle them however to treatment them as soon as for all for every particular person. And that’s going to be the last word objective of our life.

Katie: And I really like that you just introduced up the interplay of all of the totally different microbiomes throughout the physique as effectively and the way you’re taking a look at all of those, as a result of a few of my early analysis was in oral well being and studying as an example that strep mutants and the micro organism that trigger gingivitis don’t each exist on the similar time. And it’s because we’ve an oral microbiome. And if it will get out of stability in a single path or the opposite, you’re gonna find yourself with these issues. However the reply just isn’t sterilizing your mouth and killing all micro organism similar to we wouldn’t need to within the intestine. It’s getting a wholesome oral microbiome that has that ecosystem that it wants. Similar factor with the intestine. And such as you mentioned, you’re taking a look at these all through the entire physique. I do know your daughter’s additionally doing a little fascinating analysis with the vaginal microbiome and I’m excited to talk together with her about that.

However I feel, like we talked about at first, since our physique is extra bacterial than human, the extra we perceive about these interactions, the extra type of intricate information we are able to get to make enhancements over time and naturally there can be a most cancers connection right here. You realize, I’ve heard it mentioned that most cancers is a metabolic illness in some half. And this can be a means of…as a result of even inside a person, in case you’re taking a look at a metabolic illness, you’re taking a look at, “Okay, we have to get blood sugar in test. We have to get blood strain in test. We have to get weight problems measures in test.” However the way in which to do this’s gonna be totally different for each single individual.

Naveen: I feel it’s a metabolic and inflammatory illness. So, I imply, it’s brought about…power irritation is a root reason for power ailments. Nevertheless, what causes the irritation in our physique is totally different for every particular person. So despite the fact that it’s the irritation that could be on the root trigger however the underlying causes for that irritation are very, very totally different. And as you talked about, our daughter is, …has this firm referred to as Evvy, E-V-V-Y, which seems to be on the vaginal microbiome. And to me, what she’s doing is so phenomenal and particularly your viewers, each single girl ought to try this as a result of that’s actually…goes to be…, numerous ladies endure by way of most of the ailments that we as males would by no means perceive. And that to some extent is, , largely reproductive organ and most of the instances the later analysis exhibits that vaginal microbiome is concerned in preterm delivery, within the well being of the infant and all of the issues that you just talked about because the child goes by way of the delivery canal. All of the issues that come out in truth are contributory from the vaginal microbiome. So, my excessive suggestion…once more, I’m biased. I feel each girl must be doing the Evvy take a look at, proper.

Now, coming again to the stuff you talked about that, , human well being is advanced however as soon as we perceive biochemical stage what’s going on, that’s the explanation as an alternative of taking a look at organisms and as an alternative of taking a look at DNA, we centered on the gene expression or RNA. We centered on what microbes are producing. Wanting on the complete physique. And I feel, Katie, I wanna level out that the merchandise that you just construct for oral well being are a number of the finest merchandise as a result of, to me, what’s the largest gamechanger is individuals thought the organisms have been your enemy. So, they’ve this Listerine. Kills 99% of all of the micro organism in your mouth. For heaven’s sake, don’t try this. Whenever you kill the ecosystem in your mouth, it really destroys the entire digestive tract. And I wanna simply emphasize, , to individuals when our moms informed us to chew our meals, she didn’t ask us to chew the meals as a result of they thought the meals was too massive to go down our esophagus, proper. It was really was while you chew your meals, you’re permitting the oral microbiome in your saliva to truly predigest the meals, and by predigesting the meals…along with predigesting, it additionally sends the sign to the intestine and to the physique about what’s coming down. So, when it tastes candy, it begins to launch the sign for pancreas to launch the insulin, as a result of it is aware of the candy stuff is coming down.

So, the primary factor is that we have to permit the oral microbiome to predigest the feed so your small gut can now take in the vitamins which can be already predigested. So, if you find yourself…so two issues you have to take into consideration right here. And one is if you find yourself careworn and you might be consuming your meals, it doesn’t get correctly digested and right here is why. If you find yourself careworn, you might be in a battle or flight response. And the primary factor that occurs while you’re in battle or flight response is your digestive system shuts down. Bear in mind why it was designed. Whenever you’re operating away from a tiger, at the moment, the physique knew there isn’t a level worrying about digesting your meals as a result of both you’re gonna be lunch for another person otherwise you’re going to outlive. And in case you grew to become lunch for another person, it didn’t matter. And in case you survive, guess what? The stress went down and also you moved from sympathetic mode to parasympathetic mode and you could possibly digest your meals.

Whenever you come from work and you might be careworn, what can we inform individuals? Earlier than you eat, do the gratitude. Why is that? It’s since you need to convey your physique from sympathetic mode into parasympathetic mode. Eliminate battle or flight response. By taking the deep breath, by doing the gratitude, what you might be doing is definitely permitting your physique to have the ability to be able to digest the meals. Then while you chew your meals, you’re permitting your saliva and oral microbiome to truly predigest your meals. And these are easy strategies we realized within the historic tradition however we now know scientifically why did they are saying that, proper. We inform…like, Katie, it’s possible you’ll not know that my mother and pa and our faith, they don’t eat after sundown. And I all the time surprise why would that be. And it seems as a result of you have to have three or 4 hours of break after you eat meals earlier than you fall asleep. So, they made that as a faith don’t eat after sundown so as a result of individuals will get three, 4 hours of digestion. So, in truth telling that, …and that to me was actually the factor that we realized as a part of our tradition. Truly, seems we’re very scientific.

And I wanna come again to the oral merchandise. I feel individuals have to be actually excited about oral microbiome well being and utilizing the precise oral toothpaste, oral issues that…, probiotics. And the merchandise, a number of the merchandise that you’ve got, Katie, are designed to reinforce your oral well being and oral microbial actions or oral microbial ecosystem in your mouth. And I feel everybody who’s listening to it to start out listen as a result of that’s the primary. Your mouth really is the start of your digestive tract. It isn’t merely a gap to your digestive tract. It’s the path of the digestive tract the place the digestion occurs.

Katie: I completely agree. I feel very multifaceted however begin with the mouth is so essential. And I really like a few the stuff you simply talked about about why we don’t digest meals if we’re careworn and we all know, in fact, that People reside in a power state of stress usually. And one factor I’ve turn into keen on…, there’s a cause many cultures additionally pray or meditate proper earlier than consuming, which additionally helps the physique get into parasympathetic or you’ll be able to merely do respiration workout routines. Do some field respiration to calm your nervous system. I really like that your loved ones naturally from a non secular perspective stopped consuming at sundown. I’ve realized in my very own life that I do nice after I time restricted eat and for a very long time I might wait and never eat until midday after which eat later within the day. And I seen after I shifted that to consuming and stopping by sundown, I really feel so significantly better and it goes to that time you talked about about letting your physique end digesting earlier than you sleep in order that while you’re sleeping, you may be therapeutic and your physique can get into autophagy and you’ll allocate sources to all of the pure processes the physique has inbuilt to maintain us wholesome.

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And I additionally wanna piggyback on what you mentioned about the identical cause we don’t wanna kill our oral microbiome is identical cause we don’t wanna kill our intestine micro organism as effectively however I nonetheless see individuals type of hopping on the bandwagon of those actually harsh cleanses or in fact individuals typically take antibiotics for causes whether or not they should or not. And people can each have a reasonably harsh affect on the intestine. And so, I’d love to speak about it. Perhaps if somebody is aware of they’ve been on antibiotics earlier than or they know they’ve a intestine concern associated to essentially type of killing a few of these good micro organism. Clearly, Viome helps with this however type of, like, what may be executed? How can we assist repair it?

Naveen: So, very first thing is, , earlier than you go begin taking quite a lot of issues is to know, what’s the state of your intestine micro organism? So do a Viome take a look at, perceive the place it stands. And then you definately begin to have a look at what you…, we let you know what are the meals it is best to eat. And once more, taking quite a lot of the fermented meals particularly while you’re making an attempt to repopulate or rebootilate your intestine microbiome, actually the issues must be diversification. So as an alternative of simply taking one kind of probiotics, you need to be taking kombucha, the kimchi, the…, all of the fermented meals you’ll be able to presumably get your palms on. So, whether or not it’s a yogurt or, , at the least oat milk yogurt in case you can. I imply, I’m an enormous fan that I feel dairy…in truth for lots of the individuals, dairy is the massive downside. Now I’m not saying it’s for everybody however quite a lot of the individuals, dairy could possibly be an enormous downside. And the mammalian merchandise really could possibly be an enormous downside for some individuals and never for others.

So, I’m not the one who is preaching veganism right here in any respect. What I’m saying is know what is sweet for you. There are lots of people who can eat pink meat for all of their life and reside to be 100, and the explanation for that’s pink meat accommodates clearly as you all know, choline and carnitine that may get transformed by our intestine microbiome into issues like TMA. And I discussed TMA is the one which will get absorbed within the blood, causes the TMAO which causes the center illness. So, it’s not the pink meat that causes the center illness. It’s the byproduct of how the pink meat is digested in some those who produce TMA. So, in case your TMA manufacturing is low, it is best to eat pink meat if you wish to as a result of it’s not gonna hurt you. And that’s actually the purpose is to know, don’t merely ban meals and complete class of meals.

One other factor that we realized…we printed a paper having analyzed over 100,000 individuals at the moment on growing older. And what we discovered, Katie, that you could be discover actually fascinating is individuals who have been on these fad diets like, , keto weight loss program or paleo weight loss program have been the worst offender of their organic age. The individuals who have been on keto weight loss program in truth have been three to 5 years older than their chronological age and the identical is true for paleo weight loss program. It seems that people who find themselves on balanced weight loss program, which means they have been consuming their carbs however not quite a bit however they have been consuming their regular carbs, they have been consuming their protein, they have been consuming their fats they usually have been consuming the protein, they have been way more balanced, have been really higher off biologically than slicing out the entire nutrient group utterly.

Katie: That is sensible, that we’d like the range. And I’ve realized increasingly more as effectively that I feel the simplistic model all of us realized, hopefully realized in class was about simply type of energy in, energy out. And I’ve heard it mentioned, , our physique’s not a checking account. It’s a chemistry lab. And so, I now attempt to eat for maximal micronutrient and nutrient density in meals, not simply hitting or not hitting goal calorie ratios as a result of it’s a lot extra numerous and essential than that.

And what’s subsequent for Viome? I’m curious as a result of I do know you’re always doing analysis right here, and such as you mentioned, your objective is to sort out power illness in its entirety. So, what’s within the pipeline for you guys?

Naveen: Truly, I discussed that subsequent take a look at we’re launching in June is a full physique intelligence. We’re launching a most cancers detect take a look at. And we’re making our dietary supplements and probiotics increasingly more exact for each particular person since we make it for every particular person. We’re, , making an attempt to do further checks now and our objective is to launch within the subsequent six months one other take a look at which is gonna be extra, like, a proteomics take a look at as a result of the issues we can not see within the blood as a result of they’re produced some other place. So, can we measure issues, , the proteins for a Hashimoto illness? Can we measure issues like lipopolysaccharide binding protein that may predict when you’ve got a leaky intestine by taking a look at LBP, by taking a look at CRP which really is completed within the liver? So, we’re going to have the ability to really measure further issues along with simply those that we’re measuring, and the extra data we are able to be taught, the higher suggestions we make. So, our hope is to proceed to launch these checks that give us higher and higher insights and which means we are able to make increasingly more exact suggestion for every particular person.

Final objective actually is to know…as you say, the human physique is a chemistry lab. We have now mainly biochemical reactors in our physique. Your physique is a biochemical reactor. And that’s the factor individuals want to know that the gene expression tells you what biochemistry is occurring within the physique. And that’s a cause…and actually, Viome is the one firm that does take a look at the gene expression as a result of there isn’t a different firm that has this know-how. And I feel individuals who have listened to your earlier podcast, we talked about, this specific know-how got here out of Los Alamos Nationwide Lab the place that they had the laboratory for biodefense undertaking. And that’s the explanation nobody else can do it as a result of it took 10 years and multibillion {dollars}’ price of sources to develop this know-how. Sadly, we have been very lucky to have the ability to get the license to have the ability to use this know-how to assist the humanity get higher. And if our mission was merely to earn cash, we’d not have been in a position to license this know-how, proper.

So, the actual fact right now we’re merely centered on making each single individual be higher. You realize, our mission on day one was what if we may perceive the human biology at a molecular stage so we are able to forestall, diagnose early and treatment these power ailments together with most cancers and growing older? And I feel quite a lot of the individuals who have heard you and I discuss previously, that I misplaced my dad to most cancers and that was one of many largest motivator for me as a result of if I had began this firm half a decade earlier than I did, I may have probably saved my dad. And, , having watched him undergo that ache or struggling by way of most cancers I noticed that despite the fact that I couldn’t save him, I may dedicate my life to saving everybody else. And that will likely be my means of letting him know that, , I’m so happy with what he…how he raised us as a baby and giving us every little thing we’ve so we’re in a position to save everybody else’s family members whether or not it’s from coronary heart illness or diabetes or despair, nervousness or most cancers.

And my hope actually is that in our lifetime we are going to completely eradicate most cancers from the human physique. And if I have been to make a prediction right now, I’ll let you know inside a decade I feel we are going to eliminate most cancers from the human physique.

Katie: That’s an enormous declare and I hope we’re on monitor for that as effectively. I’ve misplaced two prolonged members of the family within the final couple of months alone to most cancers in addition to a few of my grandparents. And it’s no secret that these are all nonetheless very a lot on the rise proper now and I’m positive the power stress of the final couple of years just isn’t serving to that downside. So, I’m grateful that there are sources such as you, and I’ve executed Viome. I’m doing an up to date one proper now so I can report again with my outcomes on that. However I additionally am gonna ensure…I do know you’ve provided a reduction code for the Viome testing. In order that hyperlink will likely be within the present notes for you guys listening at wellnessmama.fm. You’ll find the low cost code and the hyperlink on to it there. And to verify I respect your time, there’s a pair final questions I might like to ask you. The primary being if there’s a e-book or a lot of books which have profoundly influenced your life. And if that’s the case, what they’re and why?

Naveen: Yeah, so the e-book that basically influenced me…there’s a e-book by Clayton Christensen, . I really like the person and I noticed him earlier than he died. The e-book he wrote, “How Will You Measure Your Life?” And to me it was such a profound e-book which tells you that you need to be 100% trustworthy. You can’t be 99% trustworthy as a result of as soon as you’re taking a step down of this honesty, it’s a slippery slope and there’s no stopping it. When you make an exception to one thing, there’s simply no going again however there’ll all the time be one more reason to make an exception. And so, you need to focus your self to by no means, ever compromise in your rules that you just stand for. And that was simply completely a wonderful e-book I learn.

You realize, the e-book that additionally…I imply, clearly I wrote a e-book referred to as “Moonshots” that’s actually about making a mindset of abundance somewhat than a mindset of shortage. And the elemental perception that I’ve is that there’s nothing that people will not be able to doing if we really get our mindset to imagine we are able to. So, any time when somebody says, “I can or I can’t,” it’s true as a result of it’s as much as them to resolve whether or not they can or they’ll’t. That when you imagine one thing is inconceivable, it turns into inconceivable for you and nobody else. And so, you might be utterly in management. The one factor you’ll be able to’t do is what you’ll be able to’t think about. All the pieces else is feasible.

Katie: I really like that. I do know you and I each increase our children with that mindset and yours are older and doing superb issues out on the earth already and mine are at first phases of that. And lastly, what parting recommendation would you want to go away with the viewers right now? Could possibly be associated to one thing we’ve talked about or totally unrelated.

Naveen: I might say dream so massive that individuals assume you’re loopy. Meaning by no means let somebody let you know that you could’t do it. Fall in love with your self as a result of the day you fall in love with your self is the day the world will fall in love with you. Loving your self just isn’t about being self-conceited. Loving your self is about not searching for another person’s approval to do the issues that imply quite a bit to you. Comply with your coronary heart, comply with your intestine, hearken to your intestine and comply with what it tells you. Discover a goal in life. When you discover a goal in life, you’ll by no means ever assume it’s work. I rise up daily at 4 a.m., and that’s my recommendation to everybody. Everytime you rise up within the morning, in case you’re not leaping out of the mattress, it is best to give up what you might be doing as a result of that’s not your calling, as a result of while you discover your calling, you’ll not be mendacity down within the mattress. You soar out of the mattress with pleasure wanting to resolve that downside.

And, Katie, I simply need to reiterate, I met your children and I do know I keep in mind the oldest one and I gave him the Moon rock at the moment. I’m telling you your children are going to truly transfer this humanity ahead. You might be elevating these youngsters with the mindset that every little thing they need to do, they’ll. And each mom who’s listening to it simply ought to know that parenting is definitely very counterintuitive. And, Katie, you and I’ve talked about it quite a lot of instances. Like, after we increase our kids, we inform them, “Our love for you is unconditional however our approval just isn’t.” And what which means is solely is that we’ll all the time love you, we’ll all the time be there for you, however I’m not gonna let you know I’m happy with you until you do issues that make us happy with you. And that’s actually the factor about telling the kids that their success won’t ever be measured by how a lot cash they’ve within the financial institution. It is going to be measured by what number of lives they enhance. And the humility is an indication of success as a result of in case you nonetheless have iota of vanity left in you, which means you’re nonetheless making an attempt to show one thing to your self or another person. And humility tells you not have to do this, proper. And that may be a true signal of success. And all I can say is I’m so happy with each one in every of your youngsters, Katie. And I can not look forward to them to develop up and truly do issues that may make our kids’s and grandchildren’s life higher.

Katie: Oh, thanks a lot for saying that. Individuals who don’t know, you and I first met and actually bonded over really parenting earlier than we ever talked about well being. And we share that similarity. I inform my children daily, “I really like you unconditionally and there’s nothing you ever must do to earn my love and there’s nothing you could possibly ever do that may take away from my love.” However you’re proper. Additionally, I need that, like, their delight to come back from within, like…and I inform them usually, “You will need to really feel actually happy with how exhausting you labored and you should…” As a result of I need them to have that inside them and that self-love.

And because of this I’m so grateful each single day that I get to speak to our viewers that’s listening right now of mothers, as a result of I feel mothers have such a tremendous distinctive capacity to essentially shift the way forward for humanity by how we mother or father our children and by serving to type these future leaders. And for individuals who aren’t already acquainted with you, I might encourage you to hearken to our previous interview since you inform extra of your story in that one and also you very a lot stroll the stroll of this, of getting constructed all these superb issues after which now serving to your children on their life journeys and your spouse in her personal proper is unimaginable as effectively. So very grateful in your complete household and for all that each one of you might be doing on the earth and in your time right now. I understand how busy you might be and I’m so grateful you took the time to be right here.

Naveen: Oh, Katie, it’s all the time an honor and a pleasure to be talking with you, and I’m trying ahead to our subsequent dialog.

Katie: And thanks, as all the time, to all of you for listening and sharing your most beneficial sources, your time, your vitality, and your consideration with us right now. We’re each so grateful that you just did. And I hope that you’ll be a part of me once more on the subsequent episode of the “Wellness Mama” podcast.

 

Should you’re having fun with these interviews, would you please take two minutes to go away a score or overview on iTunes for me? Doing this helps extra individuals to seek out the podcast, which suggests much more mothers and households may gain advantage from the data. I actually admire your time, and thanks as all the time for listening.

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